Abstract

SILICA-SUPPORTED METHANESULFONIC ACID: AN EFFICIENT, HETEROGENEOUS CATALYST FOR BENZOXAZOLE SYNTHESIS

Sujit S. Mathakari*

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Abstract

In the present research work, we have described synthesis of a series of benzoxazoles through the cyclisation of 2-aminothiophenol with aryl and heteroaryl aldehydes. The reported protocol is very much efficient in attendance of 10 mol % silica supported methane sulfonic acid as a heterogeneous catalyst in 10 mL CH3CN solvent at 60 oC. Use of noncorrosive, non-toxic and efficient catalyst at ambient temperature are the key advantages of reported method and it comes with certain additional compensations like shorter reaction time, simple work-up technique, high yields, recyclability of catalyst and easy availability.

Keywords: SiO2-MSA; Cyclization; Benzoxazoles; Heterogeneous catalyst; Efficient protocol.