Abstract

A REVIEW ON SYNTHESIS AND BIOLOGICAL ACTIVITY OF BENZOTHIAZOLE DERIVATIVES

Swaroopa H. M., Hamsa G. B.*, Ranjitha N. D. and Saptha S.

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Abstract

Benzothiazole is a bicyclic heterocycle having a thiazole ring. The core structure of thiazole consists of a five membered ring containing sulfur and nitrogen atoms at 1 and 3 positions. The analogues of benzothiazoles and its derivatives have a significant role in research area especially in synthetic, medicinal, and pharmaceutical chemistry because of their biological and pharmacological activities. In addition, benzothiazole act as core nucleus in various drugs due to their diverse biological activities. The benzothiazole possesses a wide spectrum of biological activities such as antimicrobial, anticancer, antioxidant, antiinflammatory, anticonvulsant, antimalarial and some miscellaneous activity.

Keywords: Benzothiazole, Antimicrobial, Anticancer, Anticonvulsant, Antioxidant.