Abstract

FORMULATION AND EVALUATION OF MEFENAMIC ACID SOLID DISPERSION USING DIFFERENT CARRIERS

*Subhashitha S., Saraswathi, K.B. Amrutha Rathod, Afroze, Sayeeda Tarannum, Ravi Kumar

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Abstract

The main objective of this study was to formulate and evaluate the dissolution rate of mefenamic acid solid dispersions in which Urea, polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 4000 (PEG 4000) were used as carrier for each of the formulations and compared with each other based on enhancement of bioavailability. The dissolution rate and dissolution efficiency of the prepared solid dispersions were evaluated in comparison to the corresponding pure drug. Mefenamic acid-urea (1:3) solid dispersion showed rapid and higher dissolution than the pure drug. Thus urea was found to be useful as a carrier in Mefenamic Acid solid dispersions compared to polyvinylpyrrolidone K30 and polyethylene glycol 4000 and it enhances the solubility, dissolution rate and dissolution efficiency.

Keywords: Mefenamic acid, solid dispersion, carrier, solvent evaporation, dissolution rate and solubility.