Abstract

SYNOVIAL MUCOSAL CYTOKINES AND CHAPEROKINE IN STAPHYLOCOCCUS AUREUS HUMAN SEPTIC A RTHRITIS

Ibrahim M S Shnawa*, Esraa Aa Aljenaby, Hamad A Busisi and Iiyad F Al Aga

Abstract

Human septic arthritis were clinically proven by the orthopedician in this team. S. aureus was reported in association of 27 neutrophilic synovitis out of 400 arthritis patients. Such patient infections induces local production of synovial cytokines TNF alpha, INF gamma, IL4 and the chaperokine heat shock protein HSP 70 to high levels than that of controls. The proinflammatory; TNF alpha, INFgamma, balanced by the anti-inflammatory IL4 and HSP70 representing the TH1/TH2 balance state. Hence, S. aureus initiate natural neutrophilic, humoral and cellular responses in the synovial compartment of the common mucosal immune system during the septic human arthritis.

Keywords: Septic arthritis, synovum, common mucosal immune system, TH1/TH2 balance.