Abstract

BIOTRANSFORMATION OF DRUGS TO DRUG METABOLITES BY FUNGI ISOLATED FROM SOIL

J. Ishwarya* and Jabin

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Abstract

In this present study, the fungus was isolated from kollimalai hill soil sample by the method of serial dilution. The fungi were identified as Aspergillus sp by microscopic observation of lacto phenol red assay. The screening studies of microbial transformation were conducted for 10 different drugs. The aceclofenac, Atorvastatin and Pioglitazone showed the best conversion. Aceclofenac was taken for the preparative scale synthesis. Aspergillus sp was grown in higher quantity of media and aceclofenac was added. The crude compounds were extracted at 120 hrs and analyzed by TLC and HPLC. These results showed the maximum conversion of aceclofenac to other metabolites. The crude material was analysed by Mass spectroscopy for the studies of molecular weight determination of formed products. The soil microorganisms can be utilized for the microbial transformation of drugs. This method is the cost effective method and high yield product development. These compounds can be utilized for the pharmaceutical, toxicological and clinical trials. In future, the identification and characterization of unidentified compound will be determined.

Keywords: Aceclofenac, Drugs.