Abstract

FORMULATION AND EVALUATION OF HERBAL ANTI-FUNGAL NAIL LACQUER

P. V. Thushara*, A. P. Chaithanya, Dr. T. K. Ajith Babu, Ayisath Masaudha, Ayshath Shibla Fathimathul Nussrath Farsana

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Abstract

Onychomycosis is a fungal infection of the nail bed or nail plate that accounts for approximately 50% of all nail diseases and is the most common disorder in adults. Onychomycosis is though life threatening, they can be very painful, discomfort and disfiguring for the suffer and may produce serious physical and occupational limitations, psychological and emotional effects, and affect quality of life. Deformed nails can lead to surrounding tissue damage and may promote secondary bacterial infections. The objective of the present work was to formulate a medicated antifungal nail laquer containing Cassia tora leaf extract for the treatment of Onychomycosis. In the present study, nail laquer containing a permeation enhancer salicylic acid and release extender ethyl cellulose in different concentration is tried out and comparison of extend of drug permeation has been done among the same. Then, formulated nail lacquers were compared for physical appearance, drying time, nonvolatile content, gloss, water resistance, drug content, drug diffusion and anti-microbial studies.

Keywords: Onychomycosis; Nail lacquer; Cassia tora; Leaf extract; Salicyclic acid; Ethyl cellulose; Drying time; Gloss; Permeation enhancer; Nail plate.