Abstract

SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC POLY ETHYLCYANOACRYLATE FOR DRUG DELIVERY

Gaurav Soni* and Shikhar Rathore

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Abstract

Alkyl cyanoacrylates are found to be promising compound for utilizing both as medical adhesive & drug delivering agent for various molecules such as proteins, anti-neo plasting agent, anti-microbial agent & so on. As according to reported procedure alkyl cyanoacrylates were synthesized by utilizing LR grade reagents & under inert condition. The compound was synthesized as according to reported procedure & progress of reaction was determined by the help of TLC. Synthesized compound shows the characteristic properties & it was found to be as similar according to reported procedure such as its solubility in acetone. The structural conformation was done by performing FTIR & 1 H NMR Spectroscopy. Absence of C=C bond (stretching vibration) at 1616cm‾¹ (which was only seen in monomer) indicates the polymerization because this C=C bond only appear in the monomer. The -CN peak shifts from 2239.4 to 2248.8 cm‾¹ & it’s a diminished peak indicates polymerization of compound. Synthesized compound shows the absence of singlets which were seen only into the monomer at δ 6.5 ppm & δ 7.5 ppm. At δ 4.3 ppm & δ 1.3 ppm peaks generated due to proton present in ethyl side chain CH3 & CH2. At δ 2.6 ppm & δ 3.0 ppm peaks were arised due to proton of CH2. The peak atδ1.9ppm & δ1.0 ppm were due to –CH3 & =CH2 of ethanol & these were present both into monomer & polymer. Only oligomer of ethyl cyanoacrylate was synthesized because during thermal depolymerization of ethyl cyanoacrylate oligomer charring was observed which was supposed due to high temperature & vacuum.

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