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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

REVIEW ON ANTI-DIABETIC ACTIVITY OF SOME BENZIMIDAZOLE DERIVATIVE

Khinde Vivekanand S.*, Bavge S. B., Patel A. C., Markante Shubham and Ingle P. V.

Abstract

Benzimidazole is an important pharmacophore which was included in several biologically active compounds resulted in the development of several classes of drugs. This review discusses the synthesis of benzimidazole derivatives as a target agents for antidiabetic by different mechanism such as peroxisome proliferator – activated Receptor α transcriptional activity, glycosidases receptor, dipeptidyl peptidase IV, glucokinase, human glucagon receptor (hGCGR) antagonist, aldose reductase enzyme and stearoyl- CoA desaturase.

Keywords: Benzimidazole derivatives, Antidiabetic agentâ€™s, Pharmacological activity, Mechanism of action, Synthesis.

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