Abstract

A REVIEW ON: HERBAL DRUG THERAPY FOR DIABETES MELLITUS

Mansi Kalamkar*, Ankita Giramkar, Pranita Karanjakar, Shubhda Khamkar, Anjali Gawali

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Abstract

One of the common metabolic diseases, diabetes mellitus affects 2.8% of people worldwide and is expected to reach 5.4% by 2025. Since herbal remedies have long been a highly regarded source of medicine, they are now a growing component of contemporary, high-tech medicine. The current review provides profiles of plants (65 species) with hypoglycaemic properties that are available through literature sources from various databases, with proper categorization according to the parts used, mode of lowering blood glucose (insulinomimetic or activity of insulin secretagogues), and active phytoconstituents with activity of insulin mimetics. According to the review, plants with ability to lower blood sugar primarily come from the families Leguminoseae, Lamiaceae, Liliaceae, Cucurbitaceae, Asteraceae, Moraceae, Rosaceae, and Araliaceae. Allium sativum, Gymnemasylvestre, Citrulluscolocynthis, Trigonellafoenumgreacum, Momordicacharantia, and Ficusbengalensis are the plants that are the most active. These include roseoside, epigallocatechingallate, beta-pyrazol-1-ylalanine, cinchonainIb, leucocyandin 3-O-beta-d-galactosyl cellobioside, leucopelargonidin-3-O-alpha-L rhamnoside, glycyrrhetinic acid, dehydrotrametenolic acid, strictinin, isostrictinAccording to the review, the presence of polyphenols, flavonoids, terpenoids, coumarins, and other compounds that indicate a decrease in blood glucose levels is mostly responsible for the antidiabetic activity of medicinal plants. The management of diabetes mellitus using these plants and their active principles is also covered in the review.

Keywords: Herbal medicine, antidiabetic action, and diabetes.