Abstract

A REVIEW: ORAL FORMULATION DEVELOPMENT

Shruti Gupta* and Anoop Kumar Singh

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Abstract

Pharmaceutical formulations must meet a number of criteria depending on how they will be used, whether during the development process or as a finished product. With their unique features, new drug candidates provide the formulation scientist with practical difficulties that must be overcome in order to meet regulatory standards, time constraints, and resource constraints. In an effort to increase the medicine's bioavailability, disguise its taste, trigger a speedy beginning of action, and increase patient compliance, modern drug delivery systems have been used. Orodispersible system is a substitute for the traditional dose form that is being used to overcome all of these problems. Poor water solubility for many therapeutic molecules being developed today is a major obstacle to reaching appropriate The term "nanosizing" refers to the process of reducing active pharmaceutical ingredient (API) particle size to the sub-micron range; the final particle size is typically between 100 and 200 nm. The rate of dissolution of the API improves considerably with decreasing particle size, which may lead to significant improvements in bioavailability. This review covers the fundamentals of nanosizing, the development and characterization of nanoformulations, as well as the actual application of such formulations in vivo.

Keywords: Oral formulation, Pharmaceutical formulations, Active pharmaceutical ingredient, Tablets.