Abstract

A REVIEW ARTICLE ON ANTICANCER AGENTS FROM VARIOUS SOURCES

*Farheen A. Shah, Shailaja W. Gawande, Dr. Manisha D. Kitukale

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Abstract

Natural merchandise have afforded a chic supply of compounds that have found several applications within the fields of drugs, pharmacy and biology. at intervals the sphere of cancer, variety of vital new commercial medication are obtained from natural sources, by structural modification of natural compounds, or by the synthesis of latest compounds, designed following a natural compound as model. The seek for improved cytotoxic agents continues to be a crucial line within the discovery of recent antitumour medication. the massive structural diversity of natural compounds and their bioactivity potential have meant that many merchandise isolated from plants, marine flora and microorganisms will function “lead” compounds for improvement of their therapeutic potential by molecular modification. to boot, semisynthesis processes of latest compounds, obtained by molecular modification of the practical teams of lead compounds, ar able to generate structural analogues with bigger medicine activity and with fewer facet effects. These processes, complemented with high-throughput screening protocols, combinatorial chemistry, procedure chemistry and bioinformatics ar able to afford compounds that ar much more economical than those presently utilized in clinical observe. Combinatorial biogenesis is additionally applied for the modification of natural microbic merchandise. Likewise, advances in genetics and also the advent of biotechnology have improved each the invention and production of latest natural compounds.

Keywords: Earthly plants, Microorganisms, Endophytic fungi.