Abstract

ETHANOLIC EXTRACT OF MUSA SAPIENTUM SPOTTED PEEL TREATMENT FOR BETTER AMELIORATES CARBON TETRACHLORIDE NEPHROTOXICITY

Ajra Khan*, Pushpa Simaiya, Dr. B. K. Dubey and Dr. Deepak Basedia

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Abstract

When kidney-specific detoxification and excretion are impaired because of endogenous or exogenous toxins damaging or destroying kidney function, this condition is known as Nephrotoxicity. Ethnomedicinal plants from the traditional system of medicine viz Ayurveda and Unani, which are acclaimed by the Ayurvedic and Unani physicians to have nephroprotective properties and commonly used to treat various renal disorders, have been extensively investigated for their significant nephroprotective effects. Musa sapientum var. sylvesteris (M. sapientum var. sylvesteris) is a valuable medicinal plant which belongs to the family Musaceae. The plant widely grows in Bangladesh. Banana is generally consumed as a dessert or cooked as vegetable or made into various confections. There are various types of species in Musa genus and their pharmacological studies have been studied. In present investigation the medicinal plants Musa sapientum peel was used to investigate for their protective ability of the kidney against CCl4- induced nephrotoxicity. In our studies simultaneous supplementation of EEMS to CCl4- treated rats was found to ameliorate the renal toxicity. Therefore, it is assumed that administration of EEMS act on ROS induced by CCl4.

Keywords: Nephrotoxicity, Musa sapientum, Phytochemical Invastigation, CCl4,