Abstract

IN VIVO STUDY ON HEPATOPROTECTIVE POTENTIAL OF NAGDANTYADI GHRITA IN PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR RATS

Abhijeet A. Gawai* and Sonali Chalakh

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Abstract

Background: In the literature of Ayurveda there is reference of Gara Visha which can be co- related to artificial poison as per modern science. As per Ayurveda, Gara visha hampers the normal functioning of Yakrut i.e. Liver. Hence Acharya Charaka have mentioned ‘Nagdantyadi ghrita’(Polyherbal Medicated butter) in context of management of Gara visha (Artificial poison). As per pharma industry estimate, India consumes nearly 1500 tons of paracetamol in a month. Paracetamol, which causes hepato-nephro toxicity with indiscriminate use, is selling without any proper dosage on the strips and bottles. Material and Method: Animals required for this study i.e. Wistar rats of both sexes will be taken from Animal house. The dose for the experimental study will be calculated by extrapolating the clinical human dose of Nagdantyadi ghrita, standard drug Silymarin and Paracetamol to an animal dose. The subjects will be assessed before and after treatment for liver function test. Objective: To examine the therapeutic potential of Nagdantyadi Ghrita by analytical study and hepatoprotective action of Nagdantyadi Ghrita against hepatotoxicity induced by Paracetamol. Result: The Sample of Nagdantyadi Ghrita will be subject to Phyto chemical screening and efficacy of Nagdantyadi ghrita as hepatoprotective will be studied.

Keywords: Ayurveda, Artificial Poison, Gara, Visha, Yakrut.