Abstract

ROLE OF MODULATORS IN VARIOUS PHASES OF CRYSTALLIZATION IN RENAL STONE FORMATION

Monika Gupta*

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Abstract

Renal stones have badly affected human beings for millennia. It is the most universal chronic disease of urinary tract influencing about 10% of the total population. Many researchers are trying to reveal the method of formation of renal stones. Renal stone formation is a multifactorial problem & includes nucleation, crystal growth, aggregation and retention. Whatever, the basic cause of stone disease, nutritional, environmental or genetic factor, the actual formation of stone in kidney may be looked upon as a strictly physiochemical problem. This review paper accounts for a broad description of the process of renal stone formation & the role of modulators viz. inhibitors & promoters in different phases of renal stone crystallization.

Keywords: Renal stone, Nucleation, Crystal growth, Aggregation & Retention, Modulators, Inhibitors, Promoters.