Abstract

GREEN TECHNIQUE: APPLICABILITY OF HYDROTROPIC SOLVENT FOR ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE DRUGS

*Smita A. Navale, Sakshi S. Ghadge, Swaranjali N. Gaikwad and Gurappa Dyade

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Abstract

The great challenge in screening studies as well as formulation of new chemical entities is the solubilization of poorly soluble drugs. In order to improve the solubility of poorly water soluble drugs, hydrotropes were utilized. Water insoluble drugs rosuvastatin, Telmisartan, valsartan and nebivolol were selected for the study, and hydrotrpes sodium acetate, sodium citrate, sodium chloride and urea were prepared in the water in various strength 1%, 2.5%, 5% and 6%. Enhancement in solubility was carried out by measuring absorbance of solution on the UV-VIS spectrophotometer. Solubility profile graph were plotted in between absorbance and various strength of hydrotrope. Sodium acetate was found appreciable solvent for valsartan and sodium citrate was found beneficial solvent for rosuvastatin. During analytical method development and formulation development exploitation of hydrotropic solvent is the approach towards green technique.

Keywords: rosuvastatin, Telmisartan, valsartan and nebivolol.