Abstract

DESIGN, SYNTHESIS AND EVALUATION OF ANTI INFLAMMATORY, ANALGESIC AND ANTI PYRETIC ACTIVITY OF 7- AMINO QUINOLINE DERIVATIVES

Abhinav Prasoon Mishra, Preeti Verma and Riya Mathur*

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Abstract

Anti malarial medication is a family of active compounds employed in the treatment of malaria. Quinoline could be a versatile lead compound for planning potent bioactive compound. Thus the invention of the new safer and imp active anti -malarial drugs represents a difficult goal for such a look area. The speedy unfold of resistance to offered anti protozoa infection drugs specially Quinoline primarily based agents. Quinoline and related agents has spotted has the necessity to found various anti- malarial drug. Recent approaches aimed synthesis of Quinoline containing double effect that's double ring. Amongst alternative objectives, our current medicative chemistry programmed is organize towards the drug resistance through the event of one agent. Within the context, one among the approach we've taken is to developed double drug moiety that give most anti protozoal infection effect. the current object provide a replacement method for prepare 7-chloro-4-quinoline derivative of Formula, same quinoline compound is well prepared from this method. The current procedure gave the employment of the preceding organism of 7-chloro-4-quinoline within the synthesis of piperazine and its medically acceptable derivatives for the treatment of malaria.

Keywords: Quinoline, Piperazine, Malaria, 7-chloro-4-quinoline.