Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF METOPROLOL SUCCINATE

Dara Ananthalakshmi*, Etikala Sravya, Kothapalli Rakesh, Penaka Aishwarya, Singapogu Sivaparvathi, Vemula Kanaka Naga Lakshmi Prasanna and Dr. T. Satyanarayana

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Abstract

The main objective of the present study is to formulate Transdermal patch of Metoprolol Succinate for quick onset of action and avoid first pass effect thereby improving bioavailability. The designed to develop suitable Transdermal patch of Metoprolol Succinate, a beta-1 selective drug, it was quantified by UV spectroscopy at λmax of 223nm, using natural polymer with different ratios of Chitosan (a natural polycationic linear polysaccharide derived from chitin) with Di-butyl phthalate as a plasticizer and Dimethyl sulfoxide (DMSO) as a permeation enhancer, methanol as solvent system. Transdermal Patches containing Metoprolol Succinate were prepared by solvent casting technique-employing mercury as a substrate. Formulations F1, F2, F3, F4, F5, F6, F7 and F8 were composed of drug and Polymer with ratio 1:5. Evaluation parameter carried out for the Transdermal patch such as Thickness, weight variation, Moisture content, Drug content, folding endurance, In-vitro permeation study. Drug polymer interaction studies was carried out using FTIR studied showed there were no incompatibilities between drug and other excipients.

Keywords: Metoprolol Succinate, Chitosan, Transdermal patch, Permeation enhancer, In-vitro drug release.