Abstract

A COMHREHENSIVE REVIEW ON SOLUBILITY ENHANCEMENT BY SOLID DISPERSION METHOD

Kamaljeet Singh, Kapil Kumar*, Aparna Joshi, Ikram, Vashali Rajpoot and Priyanshi Chauhan

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Abstract

Solid dispersion as a dosage form has been established a superior option for the drugs having poor aqueous solubility. Solid dispersion is an effective way of improving the dissolution rate of poorly water soluble drugs and hence its bioavailability. Solid dispersions in watersoluble carriers have engrossed considerable interest as a means of improving the dissolution rate and bioavailability of hydrophobic drugs. It has engrossed significant interest as an efficient means of improving the dissolution rate. This article reviews the various preparation techniques for solid dispersion and compiles some of the recent technology transfers. The different types of solid dispersions based on the molecular arrangement have been highlighted.

Keywords: Carriers, solid dispersion, aqueous solubility, solubility enhancement.