Abstract

A REVIEW ON DRUG-DRUG INTERACTIONS IN RENAL IMPAIRMENT PATIENTS

Jampana Amrutha*, Beg Karishma, Kuchibatla Lakshmi Vardhani, Veeravalli Anjana Sri Satya, Natta Prathibha and Kantamaneni Padmalatha

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Abstract

Chronic kidney disease (CKD) involves a gradual deterioration of kidney function and it is typically present with other comorbidities, such as diabetes mellitus and cardiovascular conditions like hypertension, heart failure, and stroke. Globally, the prevalence of CKD is increasing, with estimates ranging from 11 to 13%. Several medications are used by them as a result of coexisting diseases and declining renal function. Drug interactions and adverse drug reactions (ADRs) in polypharmacy might arise as a result of different pathological and physiological changes caused by renal impairment. Use online or electronic calculators to calculate the dosages of medications cleared by the kidneys by the creatinine clearance or glomerular filtration rate. Reduced doses, longer intervals between doses, or a combination of the two are suggested maintenance dosage modifications. Although not all patients who take interacting medications experience negative side effects, it is nonetheless essential to take reasonable care to prevent accidents in all circumstances where interactions are conceivable. In observational studies conducted globally about drug-drug interaction, the prevalence of moderate to minor drug interactions is more than the major interactions. Drug interactions and ADRs affect the health and quality of life of patients by raising healthcare costs, and hospital stays. It has been demonstrated that drug-related clinical decision support raises patient care standards and lowers ADE rates. Using drug interaction software, together with a general knowledge of typical DDI processes and cooperation with pharmacists, doctors can prevent clinically severe DDIs and maximise drug safety.

Keywords: CKD, ADRs, Drug interactions, Polypharmacy.