Abstract

SOLUBILITY ENHANCEMENT OF ALLOPURINOL BY SOLID DISPERSION TECHNIQUE USING SUGAR CARRIERS

Bhushan Nimba Borse*, Ragini Bundela and Dr. Karunakar Shukla

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Abstract

The objective of present study is to enhanced the solubility and dissolution of allopurinol by solid dispersion using sugar carriers. The drug Allopurinol is a Xanthine Oxidase Inhibitor and is used to treat gout and certain types of kidney stones. It is conjointly accustomed stop redoubled acid levels in patients receiving cancer therapy. These patients will have redoubled acid levels because of unharness of acid from the dying cancer cells. Allopurinol works by reducing the quantity of acid created by the body but Allopurinol shows poor-water solubility. The enhancement of the bioavailability of poorly water-soluble drugs is one of the greatest challenges of drug development and several pharmaceutical technologies have been investigated. Solid dispersion is one in all these ways, that was most generally and with success applied to boost the solubility, dissolution rates and consequently the bioavailability of poorly soluble medicine. Some drugs are poorly water soluble and it is difficult to formulate dosage form which gives maximum bioavailability. So the important product not reaching the market. Many of the techniques are there which enhance the solubility of the poorly water soluble drugs, solid dispersion is one of that fruitful technique which enhance solubility, dissolution rates and the bioavailability of poorly soluble drugs Hence, In this project work an attempt will be made to increase the solubility of Allopurinol by solid dispersion using sugar carrier.

Keywords: Solubility Enhancement, Allopurinol, Solid Dispersion, Sugar Carriers’'.