Abstract

MODULATORY POTENTIAL OF CHROMIUM SUPPLEMENTATION ON GLUCOSE, LIPID PROFILE AND LIPID PEROXIDATION OF ALLOXAN-INDUCED DIABETIC WISTAR RATS

Bunza, Jafaru Muhammad*, Dallatu M. K., Bilbis L. S., Shehu B., Alhassan A. J., Leje I. M., Ngaski A. A., Jidda Muhammad Lawal, Kakako S. Ladipo, Yale B. M., Kasimu Maryam, Haruna S., Ogunwale K. A. and Ibrahim Kalle Kwaifa

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Abstract

Chromium (Cr) appeared to be one of the most promising elements in the therapeutic management of diabetes mellitus. The objective of this current study is to identify the modulatory activities of Cr on body mass index (BMI), fasting levels of blood glucose, lipid profiles and malondialdehyde (MDA) (a product of lipid peroxidation) in alloxaninduced diabetic Wistar rats. In this study, twenty-eight rats were randomly divided into four groups containing equal numbers of rats. The first group was labelled as the non-diabetic control. The second group was labelled as the diabetic control group. The third and fourth groups were diabetic groups, orally administered with 80μg/kg/day Cr and 70mg/kg/day metformin respectively. Rats weight and glucose level were determined at 1st week before dosing and at 4th week before sacrifice. On day 30, blood was collected and used for biochemical analysis. These results showed that supplementation with Cr significantly (p

Keywords: Chromium, malondialdehyde, hyperglycaemia, dyslipidaemia.