Abstract

A REVIEW: NANOSTRUCTURED LIPID CARRIER AS DRUG DELIVERY SYSTEM

Shelke Mangal M.*, Yelmame Om S., Gadekar Dhiraj R., Kashid Shivam M. and Phatangare Rushikesh D.

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Abstract

Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid Nano carrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. NLCs hold an eminent potential in pharmaceuticals and cosmetics market because of extensive beneficial effects like skin hydration, occlusion, enhanced bioavailability, and skin targeting. This article aims to evoke an interest in the current state of art NLC by discussing their promising assistance in topical drug delivery system. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale up, non-toxicity, improved drug loading, and stability.

Keywords: Nanostructure lipid carrier, Lipid, Topical, Skin.