Abstract

REVIEW ON NANOSPONGES:A NOVEL DRUG DELIVERY SYSTEM

Vrushabh Dipak Boralkar*, Dr. R. S. Wanare and Prachi Jagdish Salwatkar

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Abstract

Targeted drug delivery systems are a promising method for delivering active moieties to specified locations. However, successful molecular targeting necessitates the use of a specific delivery method. Nanosponges have considerably enhanced medication delivery by overcoming issues such as toxicity, poor bioavailability, and erratic release. Nanosponges, which can hold both hydrophilic and hydrophobic medicines, occur in a variety of shapes and sizes and are constructed of a variety of polymers. They outperform alternative delivery systems due to their regulated release pattern and focused drug administration. The researchers created nanosponges with three-dimensional porous architectures, a restricted size distribution, and great entrapment efficiency. These tiny sponges may circulate throughout the body and adhere to specific places, allowing medications to be released in a regulated and predictable manner. Crosslinking cyclodextrine with carbonyl or dicarboxylate can be used to create nanosponges (Crosslinkers).

Keywords: Nanosponges, Bioavialability, targeted delivery, Hydrophilic and Hydrophobic drugs.