Abstract

FLOATING ORAL IN–SITU GEL: A REVIEW

Shivshankar Gajanan Kadam*, Dr. Amol A. Harsulkar, Vaibhav P. Patange, Rajesh R. Suryawanshi, Shubham D. Narwade and Amol R. Kadam

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Abstract

Drugs with a restricted window of absorption in the gastrointestinal tract (GIT) are frequently constrained by poor bioavailability because of imperfect drug release and brief residence times at the site of absorption. In order to provide controlled drug delivery with an extended stomach residence period, new drug delivery systems in the form of gastro retentive systems, such as floating systems, mucoadhesive, high-density, expandable systems, have been created. Since they undergo rapid transit from the stomach/duodenum, liquid orals are more likely to have limited bioavailability since they are quickly removed from the stomach. Oral in situ gels offer an effective solution to overcome the challenges of early liquid release and short gastrointestinal residence, making them a promising option for addressing these issues. The in situ gel dosage form initially exists as a liquid before administration, but upon contact with gastric contents, one or more mechanisms trigger its transformation into a gel-like state, floats on gastric contents. This results in both increased residence and sustained release. This method is useful for both systemic and local effects of drugs. This review study provides an overview of the formation of floating oral insitu gels, as well as a summary of research conducted by multiple scientists on a variety of drugs and polymers.

Keywords: Floating drug delivery, gastric retention time, swelling polymers, crosslinking gelation, In-situ gel.