Abstract

FORMULATION DEVELOPMENT OF FAST DISSOLVING FILM

Sachin Lodhi*, Laxmikant Jayswal and Vijendra Sharma

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Abstract

Conventional vaginal delivery systems are somewhat effective; however, they still offer several disadvantages which we need to encounter in order to deliver anti-fungal therapy in an efficacious way. Disadvantages associated are leakage and messiness as in case of creams and gel, uncomfortable, efficacy is quite low as gels may not provide an exact dose because of non-uniformity and leakage, poor patient compliance, prolonged duration of therapy, low bioavailability, drug release pattern is inappropriate On the basis of film properties, 20% v/v concentration of glycerine was optimized and used in further studies of formulation development. On the basis of evaluation parameters of different batches of films batch F1 and batch F4 were found to be more appropriate and gave better results as compared to other batches. The % cumulative drug release of optimized batches F1 and F4 in simulated vaginal fluid were found to be 99.82% and 99.77% in 60 minutes respectively. The developed film of metronidazole was found to be stable for ten weeks.

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