Abstract

HYALURONAN GEL FOR POST TRAUMATIC OSTEOARTHRITIS

Sagar Ashwini Hanmant*, Wawdhane Amol Datta and V. N. Kapse

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Abstract

Globally most common mucoskeletal disorder is osteoarthritis. osteoarthritis is caused by the cartilage around your joints wearing out over time around some years. It’s the most common cause of arthritis also known as wear and tear arthritis. Post-traumatic osteoarthritis is a type of osteoarthritis that’s caused by an injury like a bone fracture or dislocation. The damage from the injury creates arthritis quickly in the affected joint. It involves destroying of articular cartilage And reactive remodelling changes That lead to formation of osteophytes And subchondral bone cyst. The joint space is lost over time. Main Causes of post traumatic osteoarthritis include intra-articular fractures, ligamentous disruptions and dislocations, meniscal injuries, and chondral fractures. Post-traumatic arthritis, like other forms of arthritis, cannot be cured or reversed, but can be managed. The goal of treatment is to relieve symptoms and stop the condition from worsening. Viscosupplementation with intra-articular hyaluronic acid is a treatment option in knee OA that is included in the professional guidelines for treatment of this joint disease, but potentially should apply to all synovial joints in order to reduce pain and improve joint lubrication. Exogenous HA can enhance chondrocyte HA synthesis, prevent the degradation of cartilage and promote its regeneration. Moreover it can reduce the production of pro inflammatory mediators and matrix metalloproteinases involved in OA pathogenesis. it can be considered as long term therapy for post traumatic osteoarthritis.

Keywords: Hyaluronic Acid, Subchondral Bone Cyst, Nanoparticles, Chondrocytes.