Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF GUDUCHI-MUSTAADI KASHAYA – A HERBAL AYURVEDA FORMULATION FOR STHAULYA

Deepak Gangwar*, A. S. Baghel and Harisha C. R.

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Abstract

Introduction: Guduchi-Mustaadi Kashaya (GMK) is a poly herbal formulation which is indicated in Sthualya (Obesity) in Charaka Samhita.[1] This formulation is mixture of five drugs and pharmacopeial standards of this formulation is not available till date. Earlier no any researchers had evaluated this formulation but to generate data of any drug is more important to reach to the final quality control (QC) parameters. Hence this study was aimed to evaluate GMK through pharmacognostical, physio-chemical parameters and HPTLC fingerprinting in the process of establishing QC data. Methods: Pre-authenticated raw drugs were procured and GMK was prepared at pharmacy, ITRA, Jamnagar. Organoleptic parameters and microscopic analysis of Kashaya was done at pharmacognosy department, ITRA, Jamnagar. Physio-chemical analysis and HPTLC of GMK was done at pharmaceutical laboratory, ITRA, Jamnagar. Result: Microscopic features of Guduchi- Mustaadi Kashaya were cross checked with API standards of individual ingredients and it was found to have characteristics of all ingredients in it. In pharmaceutical parameters; pH value was 6.0, Water soluble extract was 2.92 %w/w, Methanol soluble extract was 30 %w/w, Ash value was 10.22 %w/w, Loss on drying was 5.505 %w/w. HPTLC at 254 nm and at 366 nm showed 15 and 4 spots respectively. Conclusion: This study has generated preliminary data on Pharmacognostical, pharmaceutical parameters and HPTLC. This fingerprinting can be useful for future researchers to reproduce this formulation and to establish quality control parameter of Guduchi-Mustaadi Kashaya.

Keywords: Guduchi-Mustaadi Kashaya, Pharmacognostical analysis, pharmaceutical analysis, physio-chemical parameter.