Abstract

QUANTIFYING THE PREVALENCE AND INTERDEPENDENT RELATIONSHIP OF PCOD, OBESITY, AND DEPRESSION – A PROSPECTIVE OBSERVATIONAL, POLYCENTRIC STUDY

Dr. Pavan Kumar Yanamadala* and Nallaparaju Lalitha Sanjana

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Abstract

The most prevalent endocrinopathy, polycystic ovarian syndrome (PCOS), affects about 11.2% of women of reproductive age and is linked to metabolic disease and reproductive failure. According to the Indian Fertility Society's research from 2014, the prevalence of PCOD in India ranges from 3.7% to 22.5%. Due to the high frequency and numerous problems of PCOS, which include ovarian and menstrual disorders, infertility, hirsutism, and metabolic & psychiatric diseases, it significantly burdens the nation's healthcare system and the quality of life of the patients. A polycentric, prospective, observational, crosssectional study involving 300 women with PCOS/PCOD was carried out, in which the study subjects were divided into three age groups (15– 25 years, 26–35 years, and 36–45 years). The study's major goal was to determine the prevalence of obesity and depression in women with PCOS/PCOD and to compare it between married and unmarried women with the same condition. Clinical consequences are more common in PCOD than in other conditions. In this study, depression and BMI were examined. The subject’s socioeconomic status and clinical symptoms were elicited using a semi-structured questionnaire. Using the Hamilton Depression (HAM-D) rating scale, the severity of the depression was evaluated. For various age groups, it was determined that irregular menstrual periods (68.33%), infertility (28.33%), acne (44.6%), hirsutism (52.6%), and Acanthosis Nigricans (30%) were statistically significant. This study's participants had obesity prevalence rates of 61% and depression prevalence rates of 67%, respectively. According to this study, 36% of the participants who fall into the category of pre-obese to obese (BMI ≥ 25) were determined to be moderate to severely depressed.

Keywords: Polycystic Ovarian Syndrome (PCOS), Infertility, Insulin Sensitivity, Obesity, Menstrual Irregularity, Depression.