Abstract

REVIEW ON: GASTRO-RETENTIVE FLOATING DRUG DELIVERY SYSTEM

Prerana Maroti Lokhande*, P. S. Kawtikwar, Vrushabh Boralkar, Pranav Revaskar, Ankita Kawtikwar

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Abstract

Oral administration of medicines with a narrow absorption window in the gastrointestinal tract (GIT) is frequently hampered by poor bioavailability with conventional dosage forms due to inadequate drug release and a short residence time at the absorption site. To address this issue and maximize oral absorption of these medications, gastroretentive systems, namely floating and mucoadhesive systems, have been developed. These devices allow regulated drug delivery with extended stomach residence duration. Some floating drug delivery systems have demonstrated the ability to accommodate these fluctuations while maintaining medication release. This review focuses on GRDDS applications, physiological consideration development, and future prospects. This review describes in detail the floating drug delivery system, its classification, and the formulation parameters that influence FDDS stomach retention. In addition, this review summarises the in vitro methodologies used to assess the performance, advantages, and applications of floating systems. Floating drug delivery systems are promising solutions for controlled drug release because they eliminate the difficulties that are often encountered during the creation of pharmaceutical dosage forms.

Keywords: Floating Drug Delivery Systems, Bioavailability, Gastric residence time, Narrow absorption window.