Abstract

A REVIEW ON PELLETS AND PELLETIZATION TECHNIQUES

Shital Subhash Dhage*, Dr. A.M. Mahale, Vrushabh D. Boralkar, Prachi J. Salwatkar

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Abstract

Nowadays, the use of multiple unit dosage forms (MUDF) is becoming increasingly popular due to their many advantages over single unit dosage forms. One of the most commonly used techniques for producing MUDF is the extrusion-spheronization method. This article covers various aspects and components of the extrusion-spheronization technique. The first section discusses the different steps involved in manufacturing pellets, including granulation, extrusion, spheronization, and drying. The final section focuses on the parameters that affect pellet quality, such as formulation aspects (e.g., moisture content, granulating liquid, excipients, and API), equipment aspects (e.g., mixer, extruder, friction plate, and extrusion screen), and process aspects (e.g., extrusion temperature, extrusion speed, spheronization time, spheronizer load, spheronization speed, and drying). Additionally, this review summarizes the characterization aspects of pellets, such as particle size distribution, surface area, surface roughness, tensile strength, angle of repose, scanning electron microscopy, and accelerated stability study properties.

Keywords: Pellets, Extrusion spheronization, Pelletization Techniques.