Abstract

STUDIES ON EFFECT OF POLMER USING VALACYCLOVIR HYDROCHLORIDE

K. Sundaramoorthy*, S. Afrose Banu, P. Anusuya, M. Archana, D. Bhuvaneshwari,

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Abstract

Monolithics matrix tablet of Valacyclovir Hydrochloride where formulated as extended release tablet employing Ethyl cellulose polymer, Hydroxy propyl Methyl Cellulose polymer and extended release characterization of the formulated tablet was investigated. Sustained release tablet contain 500mg of Valacyclovir Hydrochloride were developed by changing concentration of drug polymers the 5:0.75, and 5:1.5 by direct compression. Formulation were based on the acceptable tablet properties in vitro and invivo drug release. The resulting formulations produced robust tablets with optimum hardness drug content, weight variation, disintegration and low friability. The result of in vitro and in vivo drug release studies indicated the formulations (Drug: Polymer=5:1.5) is the most successful of the study and exhibited constant and sustained release of Valacyclovir Hydrochloride release at the end of 12 hours compared with the reference standard. A decrease in the release of the drug was absorbed on increasing polymer ratio at a certain level. Further, the formulation F4 was subjected to exposure at room and accelerated condition to stability studies. There is no difference between storage temperature. And hence the formulation F4 was concluded as a better formulation.

Keywords: Valacyclovir Hydrochloride, Matrix tablet, Sustained release tablet, Ethyl cellulose and Hydroxypropyl methyl cellulose.