Abstract

THERMODYNAMIC BEHAVIOUR OF ANTIBACTERIAL SULPHOSALICYLIC DRUG IN AQUEOUS SOLUTION OF MANNOSE SOLUTIONS THROUGH DENSITY, REFRACTIVE INDEX AND UTRAACOUSTIC PROPERTIES

J. N. Chormalle, S. N. Gundale, A. V. Pawde, Rahul Jadhav and A. D. Arsule*

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Abstract

Density, refractive index and ultrasonic velocity of sulphosalicylic acid with concentration range (0.02, 0.04, 0.06, 0.08 and 0.1) mole·kg-1 in aqueous (0.025, 0.050 and 0.100) mol∙kg-1 solutions of d-mannose have been measured at T= 303.15 K. The effects of concentration of dmannose on different thermodynamic properties such as density, refractive index and ultrasonic velocity have been calculated. Derived thermodynamic properties such as apparent molar volume ( 2, V ), partial molar volume (  o V2 ), isentropic compressibility ( s K ), apparent molar isentropic compressibility (   S,2, ), partial molar compressibility ( 0 ,2,  S ) specific acoustic impedance ( z ) and atomic polarization ( a P ) are calculated by using measured properties. These properties have been explored in terms of molecular interaction between solute and cosolute

Keywords: Thermodynamic properties, molecular interaction, antiracial drug, drug solution.