Abstract

ELECTROSPUN POLYMERIC NANOFIBER FOR SUBLINGUAL DRUG DELIVERY - A REVIEW

Rajat Sharma*, Dr. N. S. Gill, and Amandeep Kaur

Abstract

Sublingual drug administration offers a viable alternative to oral drug delivery. When a quick beginning of action is required, sublingual administration offers higher patient compliance than oral administration. By avoiding hepatic first-pass metabolic processes, the fraction of the medication absorbed through the sublingual blood vessels has an excellent bioavailability. These days, polymer nanofibers are receiving more attention as a result of their amazing qualities, including high porosity and a high surface area to volume ratio. Electrospinning technology, one of their manufacturing techniques, has drawn attention as a straightforward and repeatable procedure. It is an adaptive, straightforward, and economical method to create continuous nanofibers with desirable properties as high porosity, high surface area to volume ratio, high loading capacity, high encapsulation efficiency, transport of numerous medications, and enhancement of drug solubility. Additionally, electrospun polymeric nanofibers are useful for treating wounds and have important applications in the treatment of conditions like diabetes, AIDS, cancer, and migraines.

Keywords: Sublingual, Polymer, Electrospinning, Drug delivery.