Abstract

MULTIFUNCTIONAL CARRIER PELLETS FOR PHARMACEUTICAL APPLICATION: A SYSTEMATIC REVIEW

Ankita Marotrao Deshmukh*, Ravikiran B. Wakade, Vrushabh D. Boralkar, Shubham D. Narwade and Pranav A. Revaskar

Abstract

The majority of medications are now categorised as multiparticulate systems. Engineering precision can be used to create modified release drug delivery formulations, and multi-unit systems can make patientcentric dosing very simple. Multiple-Unit Pellet Systems (MUPS) are frequently created using functional components or a neutral excipient core, both of which can act as carriers for drug loading. They can also be produced as pure API pellets or pellets with an API matrix. That study's major goal was to develop porous pellets by removing the porous material formed during the examination of different drug loading methods. The method presented in this research effort is appropriate for the manufacturing of porous pellets in that investigation. Oil loading, fluid-bed layering, and submerging the pellets in a drug solution are all methods of drug loading.

Keywords: porous pellets; functional pellet core; starting core; inert core; drug stacking; and fluidized bed coating.