Abstract

CHEMISTRY AND BIOLOGICAL POTENTIALS OF BENZOTHIAZOLES DERIVATIVES: A CRITICAL REVIEW

*Vandana Pandey, Amrita Singh and Abhinav Prasoon Mishra

Abstract

Benzothiazoles are heterocyclic dicyclic molecules with a benzene atom connected to a ring with nitrogen and sulfur atoms. Benzothiazole is used to treat a wide range of conditions, including cancer, central muscle relaxants, and neurological disorders. This review was based on the chemistry and numerous biological potentials of benzothiazoles derivatives with literature survey through Scopus, PubMed and Google Scholar. Because it is a heterocyclic molecule, benzothiazole is used as a building block in the synthesis of more complex compounds with desirable biological properties. It has the molecular formula of C7H5NS and IUPAC name as 1,3-Benzothiazole. Due to their extraordinary pharmacological potential, these molecules are of especial importance in the field of medicinal chemistry. The nucleus of benzothiazoles is used in the synthesis of many medicinal medicines. Because of their wide range of effects, benzothiazoles are also used as the central building block in a wide variety of pharmaceuticals. It has concluded for having numerous biological activities i.e., anticancer, antibacterial, antidiabetic, antioxidant, antileishmanial, anti-inflammatory, antiviral and antitubercular. In future aspect, it is highly researched moiety for its novel biological potentials.

Keywords: Benzothiazole, chemistry, biological properties, anticancer, antimicrobial.