Abstract

A COMPREHENSIVE REVIEW ON THE CHEMISTRY AND BIOLOGICAL PROPERTIES OF SEMICARBAZIDE DERIVATIVES

Swati Pathak*, Amrita Singh and Abhinav Prasoon Mishra

Abstract

Due to their vast range of biological actions and role as building blocks in many different classes of significant pharmacological compounds, semicarbazide derivatives have attracted a lot of attention. It is a white solid that dissolves in water; derived from urea. The review was emphasized on the structure, chemistry, and different biological properties of semicarbazide derivatives using in-vitro or animal models. Researchers have been focusing on semicarbazone derivative synthesis and biological evaluation because of their potential as great therapeutic agents for treating a wide variety of disorders affecting both humans and animals. The biological properties of semicarbazones and thiosemicarbazones are often linked to their coordination of metal ions. Studies have shown that the semicarbazone moiety and its many derivatives have powerful pharmacological effects. It concludes that semicarbazide analogues are highly promising in the development of new medications for the treatment of numerous epidemic and infectious diseases like cancer, epilepsy, infection (protozoa, viral etc.), hepatic-failure, pain & inflammation and many more. It would be convenient to purchase for each humankind.

Keywords: Semicarbazide, Structure, Pharmacological activity, Anticancer, antiinflammatory.