Abstract

BILAYER TABLETS: AN IDEAL APPROACH FOR EPILEPTIC SEIZURES TREATMENT

S. P. Kulthe*, P. B. Dudhe, A. A. Sheikh and K. R. Biyani

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Abstract

Anticonvulsants are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder and borderline personality disorder, since many seem to act as mood stabilizers, and for the treatment of neuropathic pain. Anticonvulsants suppress the excessive rapid firing of neurons during seizures. Anticonvulsants also prevent the spread of the seizure within the brain. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for Anticonvulsants drugs. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. In the case of bilayered tablets drug release can be rendered almost unidirectional if the drug can be incorporated in the upper nonadhesive layer its delivery occurs into the whole oral cavity.

Keywords: Anticonvulsants, Bi-layer tablets, Sustained release etc.