Abstract

FORMULATION AND EVALUATION OF HERBAL LOTION OF PSIDIUM GUAJAVA

Khush Jain*, Fariah Rizwani and Dr. Shefali Thakkar

Abstract

Background & objectives: Even today where modern medicines have been developed and are in use since very long time in form of conventional dosage forms, the need and demand for herbal drug formulations and its daily utilization have been enhancing rapidly. Plant-based derivatives, substances and their medicines have the potential of becoming market’s keen interest due to its overall effect and application in treating various disorders and even plant being the rich source of many bio-constituents it is used as a traditional medicine. The current research work is about formulating and evaluating herbal lotion made up of extract of Plant Psidium guajava. The herbal lotion was evaluated for its physical, chemical and stability studies. Methods: The leaves of Plant Psidium guajava were dried under Hot air oven, and then the powdered plant material was exposed to Soxhlet extraction with ethanol used as a solvent. Preliminary phytochemical screening along with thin layer chromatography of the active constituent was established. Four different formulations F1, F2, F3, and F4 were prepared and subjected to the evaluation parameters including physical and chemical evaluation and stability studies. Results: Formulation F2 and F3 were found to be more stable, while remaining formulations were not stable and resulted into the breakdown of the emulsion when stored for longer time. The formulations F2 and F3 had constant pH and were homogenous throughout the stability studies, and it can be easily removed after application. The stable formulations were safe in respect to skin irritation and allergic sensitization. Also, the preliminary studies showed the presence of many phytoconstituents such as alkaloids, phenols, glycosides, carbohydrates, flavonoids, steriods, saponins, glycosides, tannins and terpenoids. Conclusion: Thus, the study validates the formulation and evaluation studies carried out on the active extract of plant Guava (Psidium guajava).

Keywords: Anti-inflammatory, Herbal lotion, Psidium guajava, soxhlet apparatus, thin layer chromatography.