Abstract

THE PROTECTIVE EFFECTS OF AQUEOUS LEAF EXTRACT OF EMILIA SONCHIFOLIA ON CARDIOTOXICITY AND ANTI-OXIDANT IMBALANCE IN NORMAL ALBINO RATS DUE TO EXPOSURE TO PETROL FUMES

Ezomoh O. Olubunmi*, Chukwuma S. Anakwe, Ijok-Gwung A. Emmanuel, Osogbah Eloghene Rachael and Prohp The Prophet

Abstract

In this study, the protective potential of aqueous leaf extract of Emiia Sonchifolia in normal albino rats against cardio-toxicity and antioxidant imbalance due to exposure to petrol fumes was investigated. 21 albino rats of Wistar strain and of average weight were used in this study. The test groups were exposed to petrol fumes for 1 hour and 3 hours daily and were treated with the aqueous leaf extract of emilia Sonchifolia (400mg/kg) and vitamin E (200mg/kg) respectively for 28 days. Blood samples were collected from the submandibular vein periodically for the evaluation of the activities of lactate dehydrogenase and creatine kinase by spectrophotometric method. On the 28th day of the experiment, all the experimental animals were sacrificed and the hearts collected for histological studies and spectrophotometric antioxidant assay. Results obtained revealed that exposure to petrol fumes caused increased activities of lactate dehydrogenase and creatine kinase when compared to the normal control (P

Keywords: Lactate dehydrogenase, creatine kinase, petrol, toxicity, emilia Sonchifolia, antioxidants.