Abstract

HEPATOPROTECTIVE ACTIVITY OF THYMOQUINONE AGAINST EXPERIMENTALLY INDUCED HEPATIC DAMAGE IN RODENTS

Rushikesh Gajanan Deshmukh*, Dr. R. J. Mandade, Shreeya Sanjay Shinde, Yashkumar Rameshwar Dhole and Akash Rajaram Chawale

Abstract

Thymoquinone (TQ) is the main active constituent of Nigella sativa seeds the objective of this study was to explore the protective effects of TQ on Paracetamol and Ethanol-induced liver toxicity in the rat model. The animals were divided into several groups of 3 each and treated orally. Group 1 received the vehicle; Group 2 was given 500 Mg/Kg paracetamol; Group 3 received 25 mg/kg TQ + 500 Mg/Kg paracetamol, Group 4 received 500 Mg/Kg paracetamol + 100 mg/kg silymarin, Group 5 received ethanol 3 mg/kg, Group 6 received 3 mg/kg ethanol + 25 mg/kg TQ and Groups 7 received 3 mg/kg ethanol + 100 mg/kg silymarin, respectively. Finally, alkaline phosphatase (ALP) serum activity as well as SGPT, SGOT, Total bilirubin, total protein, and total albumin level were evaluated in the blood samples. Our findings showed that paracetamol and ethanol caused a significant increase in ALP (P

Keywords: Paracetamol, liver, Thymoquinone, Silymarin, Ethanol, Nigella sativa, Oxidative Stress.