Abstract

BIOACTIVE, SYNTHESIS OF 4-(INDOLYL)-6-METHYL-2-THIOXO- 1, 2, 3, 4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE DERIVATIVES PROMOTED BY KIO4

T. Mahesh, M. Laxman, B. Pryanka and Dr. N. Krishna Rao*

Abstract

In depth bio active study of the synthesis of a novel 4-(indol-3-yl)- 6- methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-yl) ethanone derivatives from the reaction of substituted indole -3-carbaldehydes (1.2 mmol), acetyl acetone (1.15mmol), thiourea(2.5 mmol) in the presence of KIO4 new catalyst in ethanol reflux conditions. All the titled derivatives were analysed by advanced spectroscopic data (1H NMR, 13C NMR & LCMS) and the structural determination was evaluated by elemental analysis. In addition to the all newly prepared compounds were examined by their antimicrobial activity.

Keywords: Acetylacetonate, indole-3-carbaldehydes, KIO4, Tetra hydro pyrimidines -2 -thiones, antimicrobial activity.