Abstract

CONVENTIONAL METHOD OF BIOACTIVE SYNTHESIS OF NPHENYL NICOTINAMIDE DERIVATIVES PROMOTED BY DCC

K. Naveen, D. Radhika and Dr. N. Krishnarao*

.

Abstract

In the present study, conventional method of bioactive synthesis of Nphenyl nicotinamide derivatives 4). These derivatives (4) can be prepared from nicotinoylchloride (2) with various substituted anilines (3) in the presence of DCC in ethanol at reflux. The nicotinoylchloride (2) can be obtained by nicotinic acid with thionyl chloride in the presence of MDC at reflux. All prepared compounds were characterized via FT-IR spectroscopy; some of them were characterized by 1H-NMR and 13CNMR spectroscopy. These new Nphenyl nicotinamide derivatives were tested pharmacological activities in microbial activity. Some of tested compounds showed strong activity while the other showed moderate against.

Keywords: 1H-NMR and 13CNMR spectroscopy.