Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF MATRIX TRANSDERMAL PATCHES OF IRBESARTAN

Mithelesh Chandra Ranjan*, Naveen Gupta, Dharmendra Rajput and Neeraj Sharma

Abstract

Transdermal drug delivery system (TDDS) was designed to sustain the release and improve the bioavailability of drug and patient compliance. Among the various types of transdermal patches, matrix dispersion type systems disperse the drug in the solvent along with the polymers and solvent is allowed to evaporate forming a homogeneous drugpolymer matrix. The objective of the present study was to design and formulate TDDS of Irbesartan in order to achieve a better release pattern by the solvent casting evaporation technique using ethyl cellulose, HPMC, Eudragit RLPO, propylene glycol and permeation enhancer using different ratios and characterized for thickness, weight variation, folding endurance, moisture absorption, moisture loss, drug content, drug–polymer interactions and In Vitro skin permeation study. The physicochemical compatibility of the drug and the polymers was studied by Fourier transform infrared spectroscopy. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. The formulation exhibited flexibility, uniform thickness and weight, smoothness, good drug content (94.69to 99.56%) and little moisture content. The in vitro diffusion studies were carried out using modified Franz diffusion cell using egg membrane as the diffusion membrane and the formulation followed the Zero order diffusion mechanism. The formulation containing Eudragit: HPMC as polymers showed faster release rate compared to ethyl cellulose: HPMC. The stability studies indicated that all the patches maintained good physicochemical properties and drug content after storing the patches in different storage conditions. Hence, the aim of the present study was to prepare the sustained release formulation (Transdermal patches) of the drug using different blend of polymers.

Keywords: Transdermal patches; Irbesartan; Physicochemical parameters; Penetration enhance.