Abstract

ESTIMATION OF RISPERIDONE IN TABLET DOSAGE FORM USING UV SPECTROPHOTOMETRIC METHOD

Krishna Prasad Davarasingi*, Kunapareddy Lahari Durga, Palakurthi Siva Sai Chandra, Kudeli Krishna Teja and Dr. Atla Srinivasa Rao

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Abstract

A simple, sensitive, specific, spectrophotometric method developed for the detection of Risperidone in bulk drug and Pharmaceutical formulation. The optimum conditions for the analysis of the drug were established. The λ max of the Risperidone was found to be 280 nm. The method shows high sensitivity with linearity 2 to 6μ g/ml. The lower limit of detection and the limit of quantification was found to be 1.012 and 3.036 respectively. All the calibration curves shows a linear relationship between the absorbance and concentration and coefficient correlation was higher than 0.99. The regression of the curve was Y = 0.039x - 0.002. Precision of the method was found to be 2.0325 ± 0.044 against the label claim of 2mg. The percentage recovery was found to be 102  0.188. The sample solution was stable up to 2 hours. The proposed method will be suitable for the analysis of RIS in bulk and pharmaceutical formulation)

Keywords: Risperidone, Spectroscopy, Regression, ? max.