Abstract

A COMPREHENSIVE REVIEW ON NAIL LACQUER

*Rutuja Pramod Salunke, Minal Vilas Ingale, Nikita Dadasaheb Shinde, Vaishnavi Rajendra Pingale and Akanksha Umesh Kumbhar

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Abstract

Mammal nails are specialised epidermal derivatives that serve as tools or weapons and protect the sensitive tips of fingers and toes from harm. The fingernail is a crucial component of the body because it plays a significant role in defending the finger from various wounds and infections of the nails. The finger nail aids in the precise growth of the nail skin, protects the fingertip and tissue from injuries, but it has also been abused with numerous infections and diseases, including actual contaminations. In comparison to oral therapy, transungual therapy is thought to have less adverse systemic events and more localised effects, making it a highly desired method for treating nail problems. The transungual drug delivery system is influenced by a number of variables, including the drug's molecular size, its hydrophilicity and lipophilicity, the nature of the vehicle, and the formulation effect. When nail lacquer is applied, a film is formed on the nail bed, allowing the medicine to permeate into the nail plate. Since it is challenging for the medication molecule to be directly absorbed, penetration enhancers are used for drug delivery. Nail lacquers are delivered via the nail plate via a variety of techniques, including mechanical, chemical, and physical. There have recently been a number of developments in the transungual medication delivery (distribution through the nail plate). Antifungal and antibacterial medication therapy should be used in this way to treat nail problems. Onychomycosis, a fungal nail infection, is treated using medicated nail lacquers because they are less toxic and have a shorter treatment time. Nail lacquers contain the antifungal drugs amorofine and ciclopirox. This review is based on transungual delivery of drug.

Keywords: Antifungal, Dermatophytes, Medicated nail lacquer, Penetration enhancers, Transungual.