Abstract

SULFASALAZINE INDUCED DRESS SYNDROME TRIGGERED BY AMOXICILLIN WITH EPSTEIN-BARR VIRUS REACTIVATION

Christy Merin Mathew*, Nishi Somarkutty, Dr. Bobby Abraham and Dr. Chepsy C. Philip

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Abstract

Sulfasalazine (SSZ) is a Disease modifying anti rheumatoid drug (DMARD) used for various inflammatory joint disorders. DRESS syndrome is a less commonly occurring side effect of SSZ which can get flared up with co-administration of drugs like amoxicillin.[1,2] This can occur through reactivation of latent Epstein Barr virus (EBV) infection which can also cause manifestations of DRESS syndrome worsening the patient’s condition.[2] Here we report a case of DRESS syndrome in a young lady with undifferentiated arthritis, treated with sulfasalazine, who had reactivation of EBV.

Keywords: Sulfasalazine, DRESS syndrome, Amoxicillin, latent EBV infection.