Abstract

LIPOSOME AS DRUG DELIVERY SYSTEM: AN OVERVIEW AND THERAPEUTIC APPLICATION

Nikita H. Raulkar*, Vidya P. Sabale, Madhuri S. Chopade and Narayan B. Lande

Abstract

Backgroungd: Over the past 30 years, the liposome, a closed phospholipid bilayer vesicular structure, has drawn a lot of attention as a medicinal carrier with enormous promise. To improve treatments, powerful drugs have been formulated using liposome drug delivery methods. Aiming to decrease toxicity and increase accumulation at the target region, liposome formulations have recently been developed. Objective: Liposomes are appealing drug delivery vehicles due to their capacity to encapsulate both hydrophilic and hydrophobic medicines as well as their biocompatibility and biodegradability. The majority of therapeutic uses for liposomal drug delivery target tissue, whether or not target identification molecules are expressed on the semipermeable bilayer. The physical, chemical and biological characteristics of the liposomes are described. For a variety of pharmaceuticals, liposomes are being created for drug delivery, and they have been crucial in the development of powerful medications that have improved therapy. Initially employed to research cell biological behavior, they later evolved into a drug delivery system for focusing on a particular region of action, such as tumor targeting, gene and antisense therapy, genetic immunization, and cosmetic, among other things. Conclusion: There is a bright future for liposomes in the pharmaceutical industry. This review aims to investigate the liposome drug delivery system, including its production process, characterization, and various therapeutic uses.

Keywords: Liposomes, Drug delivery system, Phospholipid, Liposome preparation, characterization.