Abstract

MACROLIDE ANTIBIOTICS: “THERAPY IN RESPIRATORY INFECTION”

Kajal Gautam*, Abhinash Saini, Pragati Bailwal and Nita Das

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Abstract

By striking the bacterial ribosome, macrolide antibiotics stop the synthesis of proteins. They cling to and partially block the growing peptide escape tube. As a result, macrolides are allowed of as "lair entrapments" that block the creation of all proteins. The translation of a small selection of cellular proteins is selectively inhibited by macrolides, according to more recent research, and their ability to do so critically depends on both the structure of the antibiotic and the sequence of the nascent protein. As opposed to acting as general inhibitors of protein synthesis, macrolides thus appear as modulators of translation. The foundation for controlling the expression of resistance genes is the contextspecific activity of macrolides. Understanding the specifics of how macrolides work can help rationally design novel medications and reveal crucial translation regulatory principles.

Keywords: Macrolides, Ribosomes, Peptides, Translation.