Abstract

FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE ORO-DISPERSIBLE TABLETS

Susmita Paul, Sushil Gurung, Kunal Misra, Suman Deb, Susan Poudyal, Srijita Chakrabarti*

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Abstract

The present study was carried out to formulate and evaluate Metformin hydrochloride orodispersible tablets by direct compression method using two superdisintegrants i.e., crospovidone and sodium croscarmellose. The produced granules were assessed for some precompression factors such as, bulk density, tapped density, compressibility (Carr's index), angle of repose, Hausner's Ratio and bulkiness. The tablets were prepared in three formulations (F1, F2 and F3) by varying the amount of superdisintegrants. Hardness, friability, wetting time, water absorption ratio, weight variation, disintegration time, and In vitro dissolution test were performed on the tablets. It was observed that F1 demonstrated the best outcome due to the 1:1 concentration of superdisintegrants, whereas F2 showed the shortest disintegration time and dissolution test.

Keywords: Hyperglycemia; Metformin hydrochloride; Orodispersible tablets; Superdisintegrants.