Abstract

CRESCENTIC GLOMERULONEPHRITIS WITH FEATURES OF SYSTEMIC LUPUS ERYTHEMATOSUS, ANTI-GBM DISEASE, AND ANCA-ASSOCIATED VASCULITIS: A RARE CASE STUDY

M. Navya Sai*, Dr. R. Ram, Dr. K. Tirumala Naik, M. Prathyusha Bai, S. Zeenath

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Abstract

Crescent-shaped lesions in the glomeruli are the hallmark of the severe kidney inflammation known as crescentic glomerulonephritis (CGN). It can be associated with various underlying conditions, including systemic lupus erythematosus (SLE), anti-glomerular basement membrane (anti-GBM) disease, and ANCA-associated vasculitis. However, the coexistence of all three conditions in a single patient is extremely rare and poses diagnostic and therapeutic challenges. This case highlights the diagnostic and therapeutic challenges posed by the rare coexistence of crescentic glomerulonephritis, systemic lupus erythematosus, anti-GBM disease, and ANCA-associated vasculitis. Early recognition and appropriate management are crucial to prevent irreversible kidney damage and improve patient outcomes in these complex cases.

Keywords: Crescentic glomerulonephritis (CGN), Systemic lupus erythematosus (SLE), Anti-glomerular basement membrane (anti-GBM), Antineutrophilic cytoplasmic antibodies (ANCA) associated vasculitis.